2-羟基-2,3-二甲基丁酸合成路线 （共 13 条）
反应条件
hydrogenchloride; CO in tetrahydrofuran
参考文献
The Standard Oil Company
Patent: US4749811 A1, 1988 ;
反应条件
hydrogenchloride 240 h; Ambient temperature;
参考文献
Mori, Kenji; Ebata, Takashi; Takechi, Shozo
Tetrahedron, 1984 , vol. 40, # 10 p. 1761 - 1766
反应条件
1: aq. H2SO4 / 20 °C 2: conc. HCl / Heating View Scheme
参考文献
Sheehan,J.C.; Howell,M.G.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2279 - 2282
参考文献
Sheehan,J.C.; Howell,M.G.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2279 - 2282
反应条件
hydrogenchloride; diethyl ether Verseifen des entstehenden Cyanhydrins mit rauchender Salzsaeure in der Kaelte;
参考文献
Pomeranz
Monatshefte fuer Chemie, 1897 , vol. 18, p. 580
反应条件
potassium permanganate; sodium carbonate
参考文献
Criegee
Justus Liebigs Annalen der Chemie, 1930 , vol. 481, p. 263,286
Chemische Berichte, 1931 , vol. 64, p. 260,264
参考文献
Perkin
Journal of the Chemical Society, 1896 , vol. 69, p. 1484
反应条件
(i) Na2S2O5, (ii) aq. HCl; Multistep reaction;
参考文献
Sheehan,J.C.; Howell,M.G.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2279 - 2282
反应条件
Produkt5:Tribrompinakolin;
参考文献
Richard; Langlais
Bulletin de la Societe Chimique de France, 1910 , vol. <4>7, p. 464
反应条件
1: (+/-)-2-hydroxy-2,3-dimethylbutanoic acid With thionyl chloride; N,N-dimethyl-formamide T=23°C; 2 h; 2: 1-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl)thiourea With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=23°C; 12 h; optical yield given as percent de;
参考文献
AMGEN INC.; CAILLE, Seb; CUI, Sheng; WANG, Silas; FAUL, Margaret
Patent: WO2010/14586 A1, 2010 ;
Location in patent: Page/Page column 24-25 ;
WO 2010/014586 A1
