DL-3-氨基-3-苯基丙酸合成路线 （共 124 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran 2: With methanesulfonic acid in tetrahydrofuran T=30°C; 3: With sodium hydroxide in tetrahydrofuran; water pH=9 - 10; Product distribution / selectivity;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; JITHENDER, Aadepu; VENUGOPAL, Bingi
Patent: WO2011/161690 A1, 2011 ;
Location in patent: Page/Page column 22 ;
参考文献
Posner
Chemische Berichte, 1905 , vol. 38, p. 2316
Justus Liebigs Annalen der Chemie, 1912 , vol. 389, p. 35,109
反应条件
1: trifluoroacetic acid 2: oxalyl chloride / CH2Cl2 3: pyridine / CH2Cl2 4: Heating 5: aq. NaOH / tetrahydrofuran View Scheme
参考文献
Ashton, Michael J.; Hills, Susan J.; Newton, Christopher G.; Taylor, John B.; Tondu, Sylvie C. D.
Heterocycles, 1989 , vol. 28, # 2 p. 1015 - 1035
反应条件
1: HCl 2: lipase Amano PS / aq. phosphate buffer / 15 h / pH 8.2 View Scheme
参考文献
Faulconbridge, Susan J.; Holt, Karen E.; Garcia Sevillano, Luis; Lock, Christopher J.; Tiffin, Peter D.; Tremayne, Neil; Winter, Stephen
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2679 - 2681
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; 18 h;
参考文献
WO2011/42145 A1, ;
Page/Page column 53-54 ;
WO 2011/042145 A1
反应条件
sodium hydroxide in 1,4-dioxane; water
反应条件
sodium carbonate in tert-butyl alcohol
参考文献
The Journal of antibiotics, , vol. 19, # 6 p. 243 - 249
反应条件
1: thionyl chloride / 2 h / Heating 2: triethylamine / benzene / Heating View Scheme
参考文献
Lebedev; Lebedeva; Sheludyakov; Ovcharuk; Kovaleva; Ustinova
Russian Journal of General Chemistry, 2006 , vol. 76, # 7 p. 1069 - 1080
反应条件
[(C6H6)(PCy3)(CO)RuH]+BF4-; cyclopentene in toluene T=120°C; 12 h; Inert atmosphereSchlenk technique;
参考文献
Kalutharage, Nishantha; Yi, Chae S.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13651 - 13655
Angew. Chem., 2013 , vol. 125, # 51 p. 13896 - 13900
反应条件
acetic anhydride T=10 - 20°C; 2 h;
参考文献
EP1484314 A1, ;
Page 9 ;
