5-溴-2-哌啶基-1-甲基吡啶合成路线 （共 5 条）
反应条件
1: 5-bromo-2-iodopyridine With isopropylmagnesium chloride in tetrahydrofuran; dichloromethane T=0°C; 0.75 h; 2: 1-methylene-piperidinium; trifluoro-acetate in tetrahydrofuran; dichloromethane T=0°C;
参考文献
Song, Jinhua J.; Yee, Nathan K.; Tan, Zhulin; Xu, Jinghua; Kapadia, Suresh R.; Senanayake, Chris H.
Organic Letters, 2004 , vol. 6, # 26 p. 4905 - 4907
反应条件
1.1: CH2Cl2 / 0.5 h / 20 °C 2.1: iPrMgCl / CH2Cl2; tetrahydrofuran / 0.75 h / 0 °C 2.2: 82 percent / CH2Cl2; tetrahydrofuran / 0 °C View Scheme
参考文献
Song, Jinhua J.; Yee, Nathan K.; Tan, Zhulin; Xu, Jinghua; Kapadia, Suresh R.; Senanayake, Chris H.
Organic Letters, 2004 , vol. 6, # 26 p. 4905 - 4907
反应条件
1.1: 85 percent / NaI; AcCl / acetonitrile / 3 h / Heating 2.1: iPrMgCl / CH2Cl2; tetrahydrofuran / 0.75 h / 0 °C 2.2: 82 percent / CH2Cl2; tetrahydrofuran / 0 °C View Scheme
参考文献
Song, Jinhua J.; Yee, Nathan K.; Tan, Zhulin; Xu, Jinghua; Kapadia, Suresh R.; Senanayake, Chris H.
Organic Letters, 2004 , vol. 6, # 26 p. 4905 - 4907
反应条件
1: N-ethyl-N,N-diisopropylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / N,N-dimethyl-formamide / 18 h / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Demont, Emmanuel Hubert; Garton, Neil Stuart; Gosmini, Romain Luc Marie; Hayhow, Thomas George Christopher; Seal, Jonathan; Wilson, David Matthew; Woodrow, Michael David
Patent: US2012/208798 A1, 2012 ;
参考文献
Keith, John M.; Barbier, Ann J.; Wilson, Sandy J.; Miller, Kirstin; Boggs, Jamin D.; Fraser, Ian C.; Mazur, Curt; Lovenberg, Timothy W.; Carruthers, Nicholas I.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 19 p. 5325 - 5329
