2-(4-氟苯基)-2-氧代乙酸乙酯合成路线 （共 13 条）
反应条件
silver(I) acetate in acetonitrile T=25°C; 12 h;
参考文献
Deng, Guisheng; Luo, Jing
Tetrahedron, 2013 , vol. 69, # 29 p. 5937 - 5944
反应条件
iodobenzene; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; water T=25 - 30°C;
参考文献
Roy, Marie-Noelle; Poupon, Jean-Christophe; Charette, Andre B.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8510 - 8515
反应条件
in N,N-dimethyl-formamide T=90°C; 10 h;
参考文献
Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP2465847 A1, 2012 ;
Location in patent: Page/Page column 14; 15 ;
反应条件
8-methylquinoline 1-oxide; Au(Ph3P)+NTf2- T=20°C; 8 h;
参考文献
Wu, Chao; Liang, Zhiwu; Yan, Dong; He, Weimin; Xiang, Jiannan
Synthesis (Germany), 2013 , vol. 45, # 18 art. no. SS-2013-H0349-OP, p. 2605 - 2611
反应条件
in acetic acid 4 h; Heating;
参考文献
Jendralla; Granzer; V Kerekjarto; Krause; Schacht; Baader; Bartmann; Beck; Bergmann; Kessler; Wess; Chen; Granata; Herchen; Kleine; Schussler; Wagner
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 2962 - 2983
反应条件
anhydrous iron chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetylacetone in N,N-dimethyl-formamide T=125°C; 6 h;
参考文献
Zhao, Ming; Kuang, Chun Xiang; Cheng, Xue Zhi; Yang, Qing
Chinese Chemical Letters, 2011 , vol. 22, # 5 p. 571 - 574
反应条件
1: 4-fluoro-1-iodobenzene With isopropylmagnesium chloride in tetrahydrofuran T=20 - 30°C; 1.16667 h; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 3: α-acetoxyacetyl chloride With copper(l) chloride in tetrahydrofuran T=30°C; Inert atmosphere;
参考文献
McLaughlin, Mark; Belyk, Kevin M.; Qian, Gang; Reamer, Robert A.; Chen, Cheng-Yi
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5144 - 5148
反应条件
2,2'-bi-1H-imidazole; copper (II) acetate monohydrate; potassium carbonate in dimethyl sulfoxide T=45°C; 5 h;
参考文献
Zhou, Chunmei; Zeng, Runsheng; Zou, Jianping
Chinese Journal of Chemistry, 2010 , vol. 28, # 2 p. 294 - 298
反应条件
1: Br2 / diethyl ether / 0 °C 2: 71 percent / acetic acid / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 10 p. 2962 - 2983
反应条件
sodium ethanolate in ethanol
参考文献
Bioorganic Chemistry, , vol. 44, p. 35 - 41,7
