2',4'-二羟基-2-苯基苯乙酮合成路线 （共 57 条）
反应条件
1: 95 percent / 1,4-diazabicyclo<2.2.2>octane / dimethylformamide / 2 h / Ambient temperature 2: 87 percent / various solvent(s) / 1 h / Heating 3: 67 percent / Raney nickel / ethanol / 1 h / Ambient temperature 4: 91 percent / pyridine, piperidine / 8 h / Heating View Scheme
参考文献
Levai; Sebok
Synthetic Communications, 1992 , vol. 22, # 12 p. 1735 - 1750
反应条件
1: PTSA / dioxane / 5 h 2: piperidine / benzene / Heating 3: sodium borohydride / ethanol / 12 h 4: potassium carbonate / acetone / 30 h / Heating 5: aq. HCl / ethanol / 0.33 h / Ambient temperature View Scheme
参考文献
Sharma, Arun P.; Saeed, Ashraf; Durani, Susheel; Kapil, Randhir S.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 12 p. 3222 - 3229
反应条件
1: 95 percent / boron trifluoride etherate, phosphorus trichloride / 50 - 60 °C 2: 79 percent / pyridine / 1.5 h / Heating View Scheme
参考文献
Vasil'ev, S.A.; Golubushina, G.M.; Kabachnyi, V.I.; Luk'yanchikov, M.S.; Molchanov, G.I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 9 p. 641 - 645
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 9 p. 38 - 41
反应条件
1: With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate in acetone T=20 - 75°C; Baker-VenKataraman transformation; 12 h; 2: With potassium hydroxide in ethanol 0.333333 h; Heating; Further stages.;
参考文献
Dai, DeMing; Weng, LingLing
Journal of Chemical Research, 2007 , # 10 p. 572 - 573
反应条件
morpholine in isopropyl alcohol T=80°C; 7 h;
参考文献
THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC.
Patent: WO2004/2470 A1, 2004 ;
Location in patent: Page/Page column 21 ;
反应条件
boron trifluoride diethyl etherate; phosphorus trichoride T=50 - 60°C;
参考文献
Vasil'ev, S.A.; Golubushina, G.M.; Kabachnyi, V.I.; Luk'yanchikov, M.S.; Molchanov, G.I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 9 p. 641 - 645
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 9 p. 38 - 41
反应条件
methanesulfonyl chloride in N,N-dimethyl-formamide T=60 - 70°C; 1 h;
参考文献
Waehaelae, Kristiina; Hase, Tapio A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3005 - 3008
反应条件
in isopropyl alcohol
参考文献
Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.
Patent: US5247102 A1, 1993 ;
反应条件
in methanol; chloroform
参考文献
Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.
Patent: US5247102 A1, 1993 ;
参考文献
Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.
Patent: US5247102 A1, 1993 ;
