1: With caesium carbonate in pyrrolidin-2-one T=130°C; 2 h; Sealed vessel; 2: With methanol in pyrrolidin-2-one; dichloromethane T=20°C; Filtering through Celite pad;
1: HCl (gas) / diethyl ether / 3 - 4 °C 2: NH3 (gas) / ethanol / 96 h / 0 °C View Scheme
参考文献
Medwid, Jeffrey B.; Paul, Rolf; Baker, Jannie S.; Brockman, John A.; Du, Mila T.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1230 - 1241