5-甲基-2,3-二(苯基)-1H-吲哚合成路线 （共 32 条）
反应条件
silver hexafluoroantimonate; [{(η5-C5Me5)RhCl}2(μ-Cl)2]; copper (II) acetate monohydrate in methanol
T=90°C; Schlenk techniqueInert atmosphere; regioselective reaction;
参考文献
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5795 - 5798
Angew. Chem., 2013 , p. 5999
反应条件
1: With Cp*Rh(H2O)3(OTf)2; oxygen; acetic anhydride in 1,1-dimethylpropan-1-ol
T=100°C; P=760.051 Torr; 2 h; Inert atmosphereSchlenk technique;
2: With sodium hydroxide in methanol; 1,1-dimethylpropan-1-ol
T=20°C; 1 h;
参考文献
Zhang, Guoying; Yu, Hui; Qin, Guiping; Huang, Hanmin
Chemical Communications, 2014 , vol. 50, # 33 p. 4331 - 4334
反应条件
1: N2H4+H2O; toluene
2: palladium/charcoal / 370 °C
View Scheme
参考文献
Allen; VanAllan
Journal of the American Chemical Society, 1951 , vol. 73, p. 5850,5853
反应条件
toluene-4-sulfonic acid
Heating;
参考文献
Sannicolo, Franco
Journal of Organic Chemistry, 1983 , vol. 48, # 17 p. 2924 - 2925
反应条件
palladium on activated charcoal
参考文献
Allen; VanAllan
Journal of the American Chemical Society, 1951 , vol. 73, p. 5850,5853
反应条件
toluene-4-sulfonic acid
Fischer indole synthesis; 0.0833333 h; Microwave irradiationneat (no solvent);
参考文献
Creencia, Evelyn Cuevas; Tsukamoto, Masayuki; Horaguchi, Takaaki
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1095 - 1102
反应条件
1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / -5 - 0 °C
1.2: 0 °C
2.1: [(η5-C5Me5)2Rh2(μ-Cl)2Cl2]; copper (II) acetate monohydrate; silver hexafluoroantimonate / methanol / 90 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Wang, Chengming; Sun, Huan; Fang, Yan; Huang, Yong
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5795 - 5798
Angew. Chem., 2013 , p. 5999
反应条件
1: Cu(BF4)2*6H2O / tert-butyl alcohol / 20 - 70 °C
2: hydrazine hydrate / ethanol / 10 h / 120 °C / |Inert atmosphere; |Sealed tube
View Scheme
参考文献
Muralirajan, Krishnamoorthy; Cheng, Chien-Hong
Chemistry - A European Journal, 2013 , vol. 19, # 20 p. 6198 - 6202
反应条件
1: Cu(BF4)2*6H2O; [{(η5-C5Me5)RhCl}2(μ-Cl)2] / tert-butyl alcohol / 16 h / 70 °C
2: hydrazine hydrate / ethanol / 10 h / 120 °C / |Inert atmosphere; |Sealed tube
View Scheme
参考文献
Muralirajan, Krishnamoorthy; Cheng, Chien-Hong
Chemistry - A European Journal, 2013 , vol. 19, # 20 p. 6198 - 6202
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; Pd2(PPh3)2Cl2; 1,4-di(diphenylphosphino)-butane / dimethyl sulfoxide / 3 h / 80 °C / |Inert atmosphere
2: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; acetic acid / 1,2-dichloro-ethane / 16 h / 70 °C / |Inert atmosphere
View Scheme
参考文献
Zhao, Dongbing; Shi, Zhuangzhi; Glorius, Frank
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12426 - 12429
Angew. Chem., 2013 , vol. 125, # 47 p. 12652 - 12656,4
