4-二甲基氨基甲基-苯甲醛合成路线 （共 11 条）
反应条件
potassium hydroxide in methanol T=20°C; Knoevenagel condensation;
参考文献
Lieber, Sonja; Scheer, Frithjof; Meissner, Wolfgang; Naruhn, Simone; Adhikary, Till; Mueller-Bruesselbach, Sabine; Diederich, Wibke E.; Mueller, Rolf
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2858 - 2868
反应条件
hydrogenchloride in methanol
T=0 - 20°C; Product distribution / selectivity;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 101 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium formate in N,N-dimethyl-formamide
T=100°C; 4 h; Inert atmosphere;
参考文献
Niu, Song-Lin; Massif, Cedrik; Ulrich, Gilles; Renard, Pierre-Yves; Romieu, Anthony; Ziessel, Raymond
Chemistry - A European Journal, 2012 , vol. 18, # 23 p. 7229 - 7242
反应条件
tetrabutylammonium chromate in chloroform
5 h; Heating;
参考文献
Metysova, Jirina; Protiva, Miroslav
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1325 - 1330
反应条件
1: 1.) Mg / 1.) tetrahydrofuran, reflux, 30 min, 2.) tetrahydrofuran, reflux, 3 h
2: 1.42 percent / tetrabutylammonium chromate / CHCl3 / 5 h / Heating
View Scheme
参考文献
Metysova, Jirina; Protiva, Miroslav
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1325 - 1330
反应条件
1: 69 percent / benzene / 1.) 4 - 7 deg C, 2.) RT
2: 1.) Mg / 1.) tetrahydrofuran, reflux, 30 min, 2.) tetrahydrofuran, reflux, 3 h
3: 1.42 percent / tetrabutylammonium chromate / CHCl3 / 5 h / Heating
View Scheme
参考文献
Metysova, Jirina; Protiva, Miroslav
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1325 - 1330
反应条件
1.1: ammonium chloride / ethanol / 0 - 20 °C
2.1: water; methanol / 20 °C
2.2: 4 h / 20 °C / Cooling with ice
3.1: hydrogenchloride / methanol / 0 - 20 °C
View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1.1: water; methanol / 20 °C
1.2: 4 h / 20 °C / Cooling with ice
2.1: hydrogenchloride / methanol / 0 - 20 °C
View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / Reflux; Inert atmosphere
2: potassium carbonate / tetrahydrofuran / Reflux; Inert atmosphere
3: bis-triphenylphosphine-palladium(II) chloride; sodium formate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Niu, Song-Lin; Massif, Cedrik; Ulrich, Gilles; Renard, Pierre-Yves; Romieu, Anthony; Ziessel, Raymond
Chemistry - A European Journal, 2012 , vol. 18, # 23 p. 7229 - 7242
反应条件
1: potassium carbonate / tetrahydrofuran / Reflux; Inert atmosphere
2: bis-triphenylphosphine-palladium(II) chloride; sodium formate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Niu, Song-Lin; Massif, Cedrik; Ulrich, Gilles; Renard, Pierre-Yves; Romieu, Anthony; Ziessel, Raymond
Chemistry - A European Journal, 2012 , vol. 18, # 23 p. 7229 - 7242
