Cbz-L-谷氨酸 1-苄酯合成路线 （共 27 条）
反应条件
1: 51 percent / DCC / ethyl acetate / 7 h / Ambient temperature
2: 26 percent / CH2Cl2; diethyl ether / 0 - 20 °C
View Scheme
参考文献
Pettit, Georeg R.; Nelson, Paul S.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2097 - 2102
反应条件
oxalyl dichloride; triethylamine
1) THF, DMF, -30 to 0 deg C, 2) THF, DMF, ether, -78 to 0 deg C; var. reag.: isobutyl chloroformate; Yield given. Multistep reaction;
参考文献
Pettit, Georeg R.; Nelson, Paul S.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2097 - 2102
反应条件
tetrahydrofuran; tributyl-amine; chloroformic acid ethyl ester
anschliessend Behandeln mit <15N>Ammoniumnitrat enthaltendem NH4NO3 und Triaethylamin in THF;
参考文献
Klieger,E.; Gibian,H.
Justus Liebigs Annalen der Chemie, 1962 , vol. 655, p. 195 - 210
反应条件
Behandlung des Reaktionsprodukts mit aether. NH3;
参考文献
Bergmann; Zervas; Salzmann
Chemische Berichte, 1933 , vol. 66, p. 1288,1290
反应条件
1: (i) nBu3N, ClCO2Et, (ii) /BRN= 605259/
2: H2 / Pd
View Scheme
参考文献
Larsen,P.O.
Acta Chemica Scandinavica (1947-1973), 1965 , vol. 19, p. 1071 - 1078
反应条件
1: 56.14 percent / TEA, hydroxysuccinimide, DCCI / tetrahydrofuran / 24 h
2: 76.5 percent / H2 / Pd/C / methanol
View Scheme
参考文献
Ogata; Ishii
Chemical and pharmaceutical bulletin, 1967 , vol. 15, # 5 p. 707 - 710
反应条件
1: EDC
2: hydrogen / Pd-C
3: sodium sulfite / H2O / 48 h / Ambient temperature
View Scheme
参考文献
Ienaga; Nakamura; Higashiura; Toyomaki; Kimura
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 8 p. 2796 - 2801
