alpha-溴苯基乙酸甲酯合成路线 （共 64 条）
反应条件
(i) SOCl2, Br2, (ii) /BRN= 1098229/; Multistep reaction;
参考文献
Klein,J.; Shekhori,E.
Israel Journal of Chemistry, 1968 , vol. 6, p. 701 - 712
反应条件
(i) NBS, THF, MeCN, (ii) H2O; Multistep reaction;
参考文献
Groebel,B.-T. et al.
Synthesis, 1976 , p. 121 - 123
参考文献
Reeve,W.; Coley,W.R.
Canadian Journal of Chemistry, 1979 , vol. 57, p. 444 - 449
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
T=20°C; 4 h;
参考文献
Charton, Julie; Girault-Mizzi, Sophie; Debreu-Fontaine, Marie-Ange; Foufelle, Fabienne; Hainault, Isabelle; Bizot-Espiard, Jean-Guy; Caignard, Daniel-Henri; Sergheraert, Christian
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 13 p. 4490 - 4518
反应条件
1: 1.) potassium iodide, anhydrous potassium carbonate; 2.) sodium methoxyde / 1.) acetone, reflux, 12 h; 2.) benzene, reflux, 7 h
2: 65 percent / lithium aluminium hydride / tetrahydrofuran / 0 deg C, reflux, 24 h
View Scheme
参考文献
Olagbemiro, T.O.; Nyakutse, C.A.; Lajide, L.; Agho, M.O.; Chukwu, C.E.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 6 p. 473 - 480
反应条件
tetra-n-butylammonium tetrafluoroborate; zinc dibromide; zinc in acetonitrile
Ambient temperature;
参考文献
Rollin, Y.; Gebehenne, C.; Derien, S.; Dunach, E.; Perichon, J.
Journal of Organometallic Chemistry, 1993 , vol. 461, # 1-2 p. 9 - 14
反应条件
pyridine in toluene
T=80°C; 2 h;
参考文献
Kerdesky, Francis A. J.; Holms, James H.; Moore, Jimmie L.; Bell, Randy L.; Dyer, Richard D.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2158 - 2165
反应条件
1: 78 percent / diethyl ether / 48 h / Ambient temperature
2: 30percent H2O2 / ethanol; CH2Cl2 / 28 h / 62 °C
3: 1.) trifluoroacetic anhydride, 2.) NaOAc / 1.) CH2Cl2, 0 deg C, 1h, then room temp., 15 min, 2.) H2O, room temp., 30 min
View Scheme
参考文献
Koskinen, Ari; Lounasmaa, Mauri
Tetrahedron, 1983 , vol. 39, # 9 p. 1627 - 1634
反应条件
1: dichloromethane / 20 °C
2: triethylamine / dichloromethane / 2 h / 20 °C
3: CuSO4‵5H2O / tetrahydrofuran; water
View Scheme
参考文献
Kowalkowska, Anna; Jonczyk, Andrzej
Synthetic Communications, 2011 , vol. 41, # 22 p. 3308 - 3317
反应条件
cross-linked enzyme crystal Altus 17 (Candida rugosa lipase) in water
2.5 h; various enzymes, time; also in the presence of various phosphonium bromides; Product distribution;
参考文献
Jones, Matthew M.; Williams, Jonathan M. J.
Chemical Communications, 1998 , # 22 p. 2519 - 2520
