反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With lithium hexamethyldisilazane in tetrahydrofuran T=-75°C; 0.5 h; 2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran T=-75 - 0°C; 3: With water in tetrahydrofuran; ethyl acetate 0.166667 h; Cooling;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG; BENTZIEN, Joerg, Martin; BOYER, Stephen, James; BURKE, Jennifer; ELDRUP, Anne, Bettina; GUO, Xin; HUBER, John, David; KIRRANE, Thomas, Martin; SOLEYMANZADEH, Fariba; SWINAMER, Alan, David
Patent: WO2010/5783 A1, 2010 ;
Location in patent: Page/Page column 115 ;
WO 2010/005783 A1