2-(3,4,5-三甲氧基苯基)乙醇合成路线 （共 20 条）
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran 2: thionyl chloride / dichloromethane 3: dimethyl sulfoxide 4: potassium hydroxide; water / ethanol / 15 h / |Reflux 5: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 20 °C / |Reflux View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
1: dimethyl sulfoxide 2: potassium hydroxide; water / ethanol / 15 h / |Reflux 3: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 20 °C / |Reflux View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
1: potassium hydroxide; water / ethanol / 15 h / |Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 20 °C / |Reflux View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
参考文献
Pepper; Hibbert
Journal of the American Chemical Society, 1948 , vol. 70, p. 67,70
反应条件
T=150 - 160°C; Hydrogenation;
参考文献
Pepper; Hibbert
Journal of the American Chemical Society, 1948 , vol. 70, p. 67,70
反应条件
thionyl chloride in pyridine
参考文献
Majchrzak; Kotelko; Guryn; Lambert; Szadowska; Kowalczyk
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 3 p. 304 - 306
反应条件
molecular sieve; pyridinium chlorochromate in dichloromethane T=20°C; 8 h;
参考文献
Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2003 , vol. 44, # 6 p. 1275 - 1278
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C / |Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 2 h / 90 °C / |Inert atmosphere 3: lithium aluminium tetrahydride / diethyl ether / 0.5 h / |Inert atmosphere View Scheme
参考文献
Soderquist, John A.; Kock, Iveliz; Estrella, Maria E.
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 1076 - 1079
反应条件
1: Py
2: N2H4
View Scheme
参考文献
Schumann,E.L. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 3, p. 567 - 582
反应条件
Dess-Martin periodane in dichloromethane
T=25°C; 1 h;
参考文献
Labruere, Raphael; Gautier, Benoit; Testud, Marlene; Seguin, Johanne; Lenoir, Christine; Desbene-Finck, Stephanie; Helissey, Philippe; Garbay, Christiane; Chabot, Guy G.; Vidal, Michel; Giorgi-Renault, Sylviane
ChemMedChem, 2010 , vol. 5, # 12 p. 2016 - 2025
