双(4-氟苯基)(苯基)甲醇合成路线 （共 7 条）
反应条件
hydrogenchloride; Petroleum ether
参考文献
Slama, James T.; Hancock, Julie L.; Rho, Taikyun; Sambucetti, Lidia; Bachmann, Kenneth A.
Biochemical Pharmacology, 1998 , vol. 55, # 11 p. 1881 - 1892
反应条件
1.1: indium(III) chloride / toluene / 0.5 h / 20 °C / |Large scale 1.2: 2.5 h / 20 - 40 °C / |Large scale 2.1: potassium hydroxide / 1,1-dimethylpropan-1-ol / 12 h / 100 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392
反应条件
1.1: indium(III) chloride / toluene / 0.5 h / 20 °C / |Large scale 1.2: 2.5 h / 20 - 40 °C / |Large scale 2.1: sulfuric acid; acetic acid / 125 - 130 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392
反应条件
hydrogenchloride in tert.-butyl-methyl ether
参考文献
Icagen, Inc.
Patent: US6288122 B1, 2001 ;
US 6288122 B1
反应条件
1: With AlCl3, aluminium chloride
T=20°C; Inert atmosphere;
2: With water
chemoselective reaction;
参考文献
Okamoto, Akiko; Kumeda, Kazuhiro; Yonezawa, Noriyuki
Chemistry Letters, 2010 , vol. 39, # 2 p. 124 - 125
参考文献
Marvel et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 914,917
Full Text Show Details
Bacon; Gardner
Journal of Organic Chemistry, 1938 , vol. 3, p. 281,283
Full Text Show Details
Bachmann; Sternberger
Journal of the American Chemical Society, 1934 , vol. 56, p. 170,171
反应条件
1: in various solvent(s)
3 h; Heating;
2: With hydrogenchloride
Further stages.;
参考文献
McNaughton-Smith, Grant A.; Burns, J. Ford; Stocker, Jonathan W.; Rigdon, Gregory C.; Creech, Christopher; Arlington, Susan; Shelton, Tara; De Franceschi, Lucia
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 976 - 982
