1-氨基-1-环己烷羧酸甲酯盐酸盐合成路线 （共 5 条）
反应条件
thionyl chloride
T=25 - 30°C; 1 h; microwave irradiation;
参考文献
Kantharaju; Babu, Vommina V. Suresh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 8 p. 1942 - 1944
反应条件
in methanol
T=0°C; Inert atmosphereReflux;
参考文献
Maegawa, Tomohiro; Otake, Kazuki; Hirosawa, Keiichi; Goto, Akihiro; Fujioka, Hiromichi
Organic Letters, 2012 , vol. 14, # 18 p. 4798 - 4801
参考文献
Takeda Chemical Industries, Inc.
Patent: US6407116 B1, 2002 ;
反应条件
1: 82 percent / ethanol; H2O / 6 h / Heating
2: 68 percent / 3 N aq. NaOH / Heating
3: 63 percent / HCl (gas) / 4 h / Heating
View Scheme
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
反应条件
1: 68 percent / 3 N aq. NaOH / Heating
2: 63 percent / HCl (gas) / 4 h / Heating
View Scheme
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
