N-(4-硝基苯基)-1-哌啶乙酰胺合成路线 （共 6 条）
反应条件
in tetrahydrofuran
T=50°C;
参考文献
Tala, Satishkumar D.; Ou, Tai-Hsin; Lin, Yi-Wen; Tala, Kiranben S.; Chao, Shu-Hsin; Wu, Ming-Hsi; Tsai, Tung-Hu; Kakadiya, Rajesh; Suman, Sharda; Chen, Ching-Huang; Lee, Te-Chang; Su, Tsann-Long
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 155 - 169
反应条件
1: 4-nitro-aniline; chloroacetyl chloride With triethylamine in tetrahydrofuran
T=20°C; 2.3 h; Cooling with ice;
2: piperidine in tetrahydrofuran
T=20°C; 14 h; Cooling with ice;
参考文献
Lombardo, Caterina Maria; Martinez, Iria Sanchez; Haider, Shozeb; Gabelica, Valerie; De Pauw, Edwin; Moses, John E.; Neidle, Stephen
Chemical Communications, 2010 , vol. 46, # 48 p. 9116 - 9118
反应条件
1: 90 percent / Et3N / tetrahydrofuran / -15 - 20 °C
2: 91 percent / methanol / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
反应条件
1: oxalyl chloride / benzene / 0.5 h
2: diethyl ether / 0.08 h
View Scheme
参考文献
Brzezinski, Bogumil
Polish Journal of Chemistry, 1983 , vol. 57, # 1-3 p. 249 - 252
反应条件
in diethyl ether
0.0833333 h; Yield given;
参考文献
Brzezinski, Bogumil
Polish Journal of Chemistry, 1983 , vol. 57, # 1-3 p. 249 - 252
反应条件
1.1: 97 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
2.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
2.2: 84 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Lombardo, Caterina Maria; Martinez, Iria Sanchez; Haider, Shozeb; Gabelica, Valerie; De Pauw, Edwin; Moses, John E.; Neidle, Stephen
Chemical Communications, 2010 , vol. 46, # 48 p. 9116 - 9118
