1-苄氧基-4-溴-2-硝基苯合成路线 （共 6 条）
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/67614 A1, 2007 ;
Location in patent: Page/Page column 38-39 ;
WO 2007/067614 A1
反应条件
1: 2-NO2 4-Br phenol With potassium carbonate in DMF (N,N-dimethyl-formamide)
T=20°C; 0.333333 h;
2: benzyl chloride in DMF (N,N-dimethyl-formamide)
T=100°C; 6 h;
3: in water
T=20°C; 10 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2006/65233 A1, 2006 ;
Location in patent: Page/Page column 88-89 ;
反应条件
potassium carbonate in acetone; acetonitrile
19 h; Reflux;
参考文献
GENZYME CORPORATION; XIANG, Yibin; HIRTH, Bradford; KANE, John, L.; LIAO, Junkai; NOSON, Kevin; YEE, Christopher
Patent: WO2010/33701 A2, 2010 ;
Location in patent: Page/Page column 98 ;
WO 2010/033701 A2
参考文献
Roll; Hoelz
Journal fuer Praktische Chemie (Leipzig), 1885 , vol. <2> 32, p. 57
反应条件
in tetrahydrofuran
T=-40°C; 4 h;
参考文献
Garg, Neil K.; Sarpong, Richmond; Stoltz, Brian M.
Journal of the American Chemical Society, 2002 , vol. 124, # 44 p. 13179 - 13184
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=80°C; Stille coupling; 12 h;
参考文献
Li, Gaoquan; Tao, Zhi-Fu; Tong, Yunsong; Przytulinska, Magdalena K.; Kovar, Peter; Merta, Philip; Chen, Zehan; Zhang, Haiying; Sowin, Thomas; Rosenberg, Saul H.; Lin, Nan-Horng
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6499 - 6504
