3,4,5-三甲氧基苄醇合成路线 （共 102 条）
反应条件
methanol-d4; palladium dichloride T=40°C; Green chemistry; chemoselective reaction;
参考文献
Wang, Hu; Li, Li; Bai, Xing-Feng; Shang, Jun-Yan; Yang, Ke-Fang; Xu, Li-Wen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 341 - 347
反应条件
1: pyridine / diethyl ether / 2 h / |Reflux; |Inert atmosphere 2: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 24 h / |Inert atmosphere; |Glovebox; |UV-irradiation View Scheme
参考文献
Doni, Eswararao; O'Sullivan, Steven; Murphy, John A.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2239 - 2242
Angew. Chem., 2013 , vol. 125, # 8 p. 2295 - 2298,4
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere 1.2: 16 h / |Inert atmosphere; |Reflux 2.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 72 h / |Inert atmosphere; |Glovebox; |UV-irradiation View Scheme
参考文献
Doni, Eswararao; O'Sullivan, Steven; Murphy, John A.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2239 - 2242
Angew. Chem., 2013 , vol. 125, # 8 p. 2295 - 2298,4
反应条件
[Ir(μ-Cl)(cyclooctene)2]2; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; lithium chloride in water; 1,3,5-trimethyl-benzene T=170°C; 20 h; Schlenk techniqueInert atmosphere;
参考文献
Olsen, Esben P. K.; Madsen, Robert
Chemistry - A European Journal, 2012 , vol. 18, # 50 p. 16023 - 16029
反应条件
1: 3,4,5-Trimethoxybenzyltriphenylphosphonium Bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: 3,4,5-trimethoxy-benzyl alcohol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 24 h; Inert atmosphereReflux; 3: With 2,2'-azo-bisisobutyronitrile; diphenyldisulfane in tetrahydrofuran 8 h; Reflux;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
1: 3,4,5-Trimethoxybenzyltriphenylphosphonium Bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: 3,4,5-trimethoxy-benzyl alcohol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 24 h; Inert atmosphereReflux; optical yield given as percent de;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
1: PBr3 / CH2Cl2 / 0.75 h / -5 °C 2: 73 percent / 2.17 h / 140 - 180 °C 3: 61 percent / NaH; 15-crown-5 / tetrahydrofuran View Scheme
参考文献
Das, Joydip; Pany, Satyabrata; Majhi, Anjoy
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5321 - 5333
反应条件
nickel in tetrahydrofuran 24 h; Reflux; optical yield given as percent de;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
Tetrahedron Letters, 2009 , vol. 50, # 25 p. 3070 - 3073
反应条件
1.1: 83 percent / DMAP; Et3N / tetrahydrofuran / 4 h / 20 °C 2.1: i-PrMgCl*LiCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 4 h / 0 °C 2.2: CuBr; P(OEt)3 / 1,2-dimethoxy-ethane; tetrahydrofuran / 0.17 h / -15 °C 2.3: 81 percent / tetrabutylammonium iodide / tetrahydrofuran; 1,2-dimethoxy-ethane / 1.5 h / 60 °C 3.1: 87 percent / aq. HCl / methanol / 0.25 h / 20 °C 4.1: 86 percent / N,N-dimethylbenzenamine; POCl3 / 1 h / 110 °C 5.1: 85 percent / NH3 / methanol / 6 h / 175 °C View Scheme
参考文献
Kofink, Christiane C.; Knochel, Paul
Organic Letters, 2006 , vol. 8, # 18 p. 4121 - 4124
反应条件
1: thionyl chloride / dichloromethane 2: potassium carbonate / dimethyl sulfoxide / 6 h / 50 °C 3: sodium chloride / dimethyl sulfoxide / 5 h / |Reflux View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
