反应条件
1.1: thionyl chloride / 2 h / |Reflux
1.2: 2 h / 20 °C
2.1: sulfuric acid / 2 h / 20 °C
3.1: palladium 10 on activated carbon; hydrogen / methanol / 20 °C
4.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C
5.1: lithium hydroxide hydrate; water / tetrahydrofuran / 20 °C
6.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C
6.2: 80 °C
View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; LI, Jijun; ZHU, Yan; HU, Yuandong; WANG, Huting; WANG, Zhe; WANG, Zanping; WEI, Yongheng; SUN, Yinghui; WU, Qiong; ZHANG, Hui; PENG, Yong; KONG, Fansheng; SUN, Ying; LUO, Hong; HAN, Yongxin
Patent: WO2013/71865 A1, 2013 ;