R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
hydroxylammonium acetate T=40°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yaozhong, Jiang; Peng, Guo; Guilan, Liu
Synthetic Communications, 1990 , vol. 20, # 1 p. 15 - 22
反应条件
water; hydroxide Title compound not separated from byproducts;
参考文献
Chapman, Daniel T.; Crout, David H. G.; Mahmoudian, Mahmoud; Scopes, David I. C.; Smith, Paul W.
Chemical Communications, 1996 , # 21 p. 2415 - 2416
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Sabot, Cyrille; Subhash, Pithani V.; Valleix, Alain; Arseniyadis, Stellios; Mioskowski, Charles
Synlett, 2008 , # 2 p. 268 - 272
反应条件
horse radish peroxidase; Escherichia coli monoamine oxidase N, D5 variant T=30°C; pH=7.0; Enzyme kinetics;
参考文献
Eve, Tom S. C.; Wells, Andrew; Turner, Nicholas J.
Chemical Communications, 2007 , # 15 p. 1530 - 1531
反应条件
1: LiAlH4 / diethyl ether / 15 h / 25 °C / other reagent,other solvent 2: trifluoroacetic acid / methanol / 1 h / 0 °C View Scheme
参考文献
Annunziata, Rita; Cinquini, Mauro; Cozzi, Franco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 339 - 344
反应条件
1.1: hydroxylamine hydrochloride / water; methanol / 25 °C 2.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 3.2: 18 h / 20 °C 4.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 18 h / 20 °C 3.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
in dimethyl sulfoxide T=25°C; Equilibrium constant;
参考文献
Zingg, S. P.; Arnett, Edward M.; McPhail, Andrew T.; Bothner-By, Aksel A.; Gilkerson, W. R.
Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1565 - 1580
反应条件
in dimethyl sulfoxide T=25°C; Equilibrium constant;
参考文献
Zingg, S. P.; Arnett, Edward M.; McPhail, Andrew T.; Bothner-By, Aksel A.; Gilkerson, W. R.
Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1565 - 1580
反应条件
sulfuric acid in water 2 h; Ambient temperature; Yield given;
参考文献
Ikota; Achiwa; Yamada
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 887 - 894
