R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
(S)-selective ω-transaminase from Ochrobactrum anthropi; L-threonine deaminase from Escherichia coli; pyridoxal 5'-phosphate T=37°C; pH=7.5; 3 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Malik, M. Shaheer; Park, Eul-Soo; Shin, Jong-Shik
Green Chemistry, 2012 , vol. 14, # 8 p. 2137 - 2140
反应条件
(S)-selective ω-transaminase from Ochrobactrum anthropi; pyridoxal 5'-phosphate T=37°C; pH=7.5; 3 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Malik, M. Shaheer; Park, Eul-Soo; Shin, Jong-Shik
Green Chemistry, 2012 , vol. 14, # 8 p. 2137 - 2140
反应条件
Chromobacterium violaceum ω-transaminase variant W60C T=37°C; pH=7; 12 h; Reagent/catalystpH-value; enantioselective reaction;
参考文献
Wang, Bo; Land, Henrik; Berglund, Per
Chemical Communications, 2013 , vol. 49, # 2 p. 161 - 163
反应条件
potassium hydroxide 1) thermal decomposition; 2) H2O, EtOH, reflux, 40 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chrzanowska; Schonenberger; Brossi
Helvetica Chimica Acta, 1987 , vol. 70, # 7 p. 1721 - 1731
反应条件
1: 1.) butyllithium / 1.) hexane, THF, -78 deg C, 3 h 2: hydroxylamine acetate / 40 °C View Scheme
参考文献
Yaozhong, Jiang; Peng, Guo; Guilan, Liu
Synthetic Communications, 1990 , vol. 20, # 1 p. 15 - 22
反应条件
in tetrahydrofuran T=-10°C; 12 h; Title compound not separated from byproducts.;
参考文献
Karnik, Anil V.; Kamath, Suchitra S.
Tetrahedron Asymmetry, 2008 , vol. 19, # 1 p. 45 - 48
反应条件
in chloroform-d1 treatment of soln. of (Pd(C6H5CHNCH(Me)C6H5)(Cl))2 with a drop of py-d5 for a few seconds at room temp.; as mixt. of isomers; monitoring by NMR;
参考文献
Albert, Joan; D'Andrea, Lucia; Granell, Jaume; Tavera, Raquel; Font-Bardia, Merce; Solans, Xavier
Journal of Organometallic Chemistry, 2007 , vol. 692, # 14 p. 3070 - 3080
反应条件
(S)-selective ω-transaminase from Ochrobactrum anthropi; pyridoxal 5'-phosphate T=37°C; pH=7.5; 24 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Malik, M. Shaheer; Park, Eul-Soo; Shin, Jong-Shik
Green Chemistry, 2012 , vol. 14, # 8 p. 2137 - 2140
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Fernandez, Elena; Hooper, Mark W.; Knight, Frances I.; Brown, John M.
Chemical Communications, 1997 , # 2 p. 173 - 174
反应条件
1: chloroform / und Erhitzen des Reaktionsprodukts mit wss.-aethanol.Salzsaeure 2: (-)-quinic acid View Scheme
参考文献
Andre; Vernier
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1931 , vol. 193, p. 1192
Annales de l'Office National des Combustibles Liquides (France), 1932 , vol. 7, p. 515
