R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
1: β-NADP+ / aq. buffer / 25 °C / pH 10 2: Reduced nicotinamide-adenine dinucleotide / aq. buffer / 25 °C / pH 9.6 View Scheme
参考文献
Abrahamson, Michael J.; Wong, John W.; Bommarius, Andreas S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 9 p. 1780 - 1786
反应条件
1: toluene / Heating 2: NaBH4 View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 16 p. 3397 - 3400
反应条件
1: triethylamine / ethyl acetate / 20 - 60 °C 2: potassium hydroxide / water / |Reflux View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
反应条件
1: 97 percent / 4 h / 160 °C 2: acetyl chloride / 16 h / Heating 3: 80 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating View Scheme
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
反应条件
Pd/AlO(OH) in toluene T=70°C; 3 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Xiong, Xiaoxia; Xu, Xinliang; Zhou, Yifeng; Weng, Chenchen
Russian Journal of General Chemistry, 2013 , vol. 83, # 12 p. 2402 - 2405
反应条件
hydrogen; aluminum oxide; ruthenium
参考文献
McGahren; Kunstmann
The Journal of organic chemistry, 1972 , vol. 37, # 6 p. 902 - 906
反应条件
1: benzene / 1 h / Ambient temperature 2: ZnBr2, HMDS / benzene / 1 h / Heating View Scheme
参考文献
Reddy; Kondo; Toru; Ueno
Journal of Organic Chemistry, 1997 , vol. 62, # 8 p. 2652 - 2654
反应条件
in water T=15 - 17°C; 0.8 h;
参考文献
Kim, Jeum-Jong; Kweon, Deok-Heon; Cho, Su-Dong; Kim, Ho-Kyun; Jung, Eun-Young; Lee, Sang-Gyeong; Falck; Yoon, Yong-Jin
Tetrahedron, 2005 , vol. 61, # 24 p. 5889 - 5894
反应条件
pyridine in chloroform
参考文献
Deshmukh, M.; Dunnach, E.; Juge, S.; Kagan, H. B.
Tetrahedron Letters, 1984 , vol. 25, # 32 p. 3467 - 3470
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile T=20°C; 22 h; Inert atmosphere;
参考文献
Tiwari, Rohit; Moraski, Garrett C.; Krchnak, Viktor; Miller, Patricia A.; Colon-Martinez, Mariangelli; Herrero, Eliza; Oliver, Allen G.; Miller, Marvin J.
Journal of the American Chemical Society, 2013 , vol. 135, # 9 p. 3539 - 3549
