R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
1: With trimethylsilyl iodide in acetonitrile T=20°C; 0.5 h; 2: With hydrogenchloride in diethyl ether; water 3: With potassium hydroxide in water
参考文献
Denmark, Scott E.; Nakajima, Noriyuki; Stiff, Cory M.; Nicaise, Olivier J.-C.; Kranz, Michael
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 7-8 p. 1023 - 1045
反应条件
heptakis-(6-O-TIPS)-β-CD; triethylamine in cyclohexane T=10°C; 12 h; Resolution of racemate;
参考文献
Asahara, Haruyasu; Kida, Toshiyuki; Iwamoto, Takuya; Hinoue, Tomoaki; Akashi, Mitsuru
Tetrahedron, 2014 , vol. 70, # 2 p. 197 - 203
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=50 - 60°C; P=4413.05 Torr; 8 h; Yield given. Yields of byproduct given;
参考文献
Takahashi; Tomita; Noguchi
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3387 - 3391
反应条件
naphthalene; sodium in ethylene glycol dimethyl ether T=20°C; 1 h;
参考文献
Yang, Qin; Shang, Gao; Gao, Wenzhong; Deng, Jingen; Zhang, Xumu
Angewandte Chemie - International Edition, 2006 , vol. 45, # 23 p. 3832 - 3835
反应条件
Candida antarctica lipase B in phosphate buffer T=70°C; pH=7; 48 h;
参考文献
Torres-Gavilan; Escalante; Regla; Lopez-Munguia; Castillo
Tetrahedron Asymmetry, 2007 , vol. 18, # 22 p. 2621 - 2624
反应条件
1: H2 / Pd(OCOCF3)2; (S,S,R,R)-TangPhos / CH2Cl2 / 24 h / 40 °C / 57000 Torr 2: naphthalene; Na / 1,2-dimethoxy-ethane / 1 h / 20 °C View Scheme
参考文献
Yang, Qin; Shang, Gao; Gao, Wenzhong; Deng, Jingen; Zhang, Xumu
Angewandte Chemie - International Edition, 2006 , vol. 45, # 23 p. 3832 - 3835
反应条件
1: m-CPBA / CH2Cl2 / 20 °C 2: H2 / Pd(OCOCF3)2; (S,S,R,R)-TangPhos / CH2Cl2 / 24 h / 40 °C / 57000 Torr 3: naphthalene; Na / 1,2-dimethoxy-ethane / 1 h / 20 °C View Scheme
参考文献
Yang, Qin; Shang, Gao; Gao, Wenzhong; Deng, Jingen; Zhang, Xumu
Angewandte Chemie - International Edition, 2006 , vol. 45, # 23 p. 3832 - 3835
反应条件
1: With sodium carbonate in toluene T=90°C; 72 h; 2: With hydrogen; palladium on activated charcoal in ethanol T=20°C; P=760.051 Torr; 0.5 h; Further stages. Title compound not separated from byproducts.;
参考文献
Hoben, Christine E.; Kanupp, Lisa; Baeckvall, Jan-E.
Tetrahedron Letters, 2008 , vol. 49, # 6 p. 977 - 979
反应条件
sodium hydroxide in dichloromethane; water pH=10 - 11;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; SATYANARAYANA, Revu
Patent: WO2011/77463 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
methoxylamine hydrochloride; n-butyllithium in tetrahydrofuran; hexane T=-78 - 60°C; 12 h; Inert atmosphereCooling with acetone-dry ice; stereospecific reaction;
参考文献
Mlynarski, Scott N.; Karns, Alexander S.; Morken, James P.
Journal of the American Chemical Society, 2012 , vol. 134, # 40 p. 16449 - 16451,3
