R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
hydrogen; Pd-BaSO4 in toluene T=70°C; P=75.0075 Torr; 24 h; Kinetics; Further Variations:Catalysts;
参考文献
Parvulescu, Andrei N.; Jacobs, Pierre A.; De Vos, Dirk E.
Chemistry - A European Journal, 2007 , vol. 13, # 7 p. 2034 - 2043
反应条件
Candida antarctica lipase B immobilized on acrylic resin in toluene T=25°C; 0.0666667 h; Resolution of racemateFlow reactor; TemperatureTimeReagent/catalyst;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
(2S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol-borane in tetrahydrofuran T=30°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2039 - 2044
反应条件
(2S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol-borane in tetrahydrofuran T=30°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2039 - 2044
反应条件
hydrogen; palladium on activated charcoal
参考文献
Sorbye, Karsten; Tautermann, Christoffer; Carlsen, Per; Fiksdahl, Anne
Tetrahedron Asymmetry, 1998 , vol. 9, # 4 p. 681 - 689
反应条件
L-ERYTHRO-(1R,2S)-2-AMINO-1-PHENYLPROPAN-1-OL; borane in tetrahydrofuran T=0°C; 24 h;
参考文献
Krzeminski, Marek P.; Zaidlewicz, Marek
Tetrahedron Asymmetry, 2003 , vol. 14, # 11 p. 1463 - 1466
反应条件
1: diisobutylaluminum hydride / tetrahydrofuran / 1 h / -30 °C 2: CF3COOH / methanol / 3 h / 25 °C View Scheme
参考文献
Hua, Duy H.; Miao, Shou Wu; Chen, Jin Shan; Iguchi, Sadahiko
Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 4 - 6
反应条件
1: 1.) ether, 0 deg C, 1 h 2.) 0 deg C 2: diisobutylaluminum hydride / tetrahydrofuran / 1 h / -30 °C 3: CF3COOH / methanol / 3 h / 25 °C View Scheme
参考文献
Annunziata, Rita; Cinquini, Mauro; Cozzi, Franco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 339 - 344
反应条件
water T=40°C; pH=7; 75 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
反应条件
novozyme 435; water T=70°C; pH=7; 120 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Ismail, Hilda; Lau, Rute Madeira; Van Rantwijk, Fred; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1511 - 1516
