反应条件
1: 1.) C2H5MgBr / 1.) Et2O, 30 min, 2.) Et2O, 0 deg C, 1 h, room temp., 2 h
2: 74 percent / H2 / PtO2 / acetic acid / Ambient temperature
3: 2 h / 180 °C
4: 1.) POCl3, 2.) NaBH4 / 1.) toluene, reflux, 1 h; 2.) MeOH, room temp.
View Scheme
参考文献
Knefeli, Frank; Mayer, Klaus K.; Poettinger, Theodor; Stoeber, Georg; Wiegrebe, Wolfgang
Archiv der Pharmazie (Weinheim, Germany), 1983 , vol. 316, # 9 p. 773 - 781
