4-甲基-5-甲基-4H-[1,2,3]三唑-3-硫醇合成路线 (共 4 条)
反应条件
1: acetic acid With 1,1'-carbonyldiimidazole in DMF (N,N-dimethyl-formamide) T=22 - 26°C; 0.666667 h; 2: [(methylamino)thioxomethyl]hydrazine With pyridine in DMF (N,N-dimethyl-formamide) T=20 - 100°C; 18 h;
参考文献
ABBOTT GMBH and CO. KG
Patent: WO2006/15842 A1, 2006 ;
Location in patent: Page/Page column 47 ;
WO 2006/015842 A1
反应条件
1: in ethanol 6 h; Heating / reflux; 2: With sodium hydroxide in ethanol; water 1 h; Heating / reflux;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 214 ;
US 20050176701 A1
反应条件
sodium hydroxide 0.5 h; Heating;
参考文献
Robert-Piessard, Sylvie C.; Leger, Jean-Michel; Kumar, Piush; Baut, Guillaume Le; Brion, Jean-Daniel
Journal of Chemical Research, Miniprint, 1989 , # 3 p. 511 - 522
反应条件
1: With dihydrogen peroxide; acetic acid in dichloromethane; water T=0 - 20°C; 2: With sodium hydroxide in water pH=12;
参考文献
LEAD THERAPEUTICS, INC.
Patent: US2010/35883 A1, 2010 ;
Location in patent: Page/Page column 81 ;