5-苯基-4-甲基-4氢-3-羟基-1,2,4-三唑合成路线 （共 11 条）
反应条件
sodium hydroxide T=150°C; 0.05 h; Microwave irradiation;
参考文献
Samanta, Sanjay; Lim, Ting Liang; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 6 p. 994 - 1001
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5143933 A1, 1992 ;
反应条件
disulfur dichloride in acetic acid 0.166667 h; Heating;
参考文献
Milcent, Rene; Nguyen, Thu-Huong
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 881 - 883
反应条件
1: 69 percent / tetrahydrofuran / 2 h / Heating 2: 60 percent / 1M aq. NaHCO3 / 24 h / Heating View Scheme
参考文献
Samanta, Sanjay; Lim, Ting Liang; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 6 p. 994 - 1001
反应条件
1: pyridine / Ambient temperature 2: 1M NaHCO3 / H2O / 17 h / Heating View Scheme
参考文献
Hoggarth
Journal of the Chemical Society, 1949 , p. 1163,1167
Journal of the Chemical Society, 1950 , p. 1579,1581
反应条件
potassium hydroxide; Montmorillonit K10 0.1 h; microwave irradiation;
参考文献
Rostamizadeh, Shahnaz; Mollahoseini, Kambiz; Moghadasi, Samar
Phosphorus, Sulfur and Silicon and the Related Elements, 2006 , vol. 181, # 8 p. 1839 - 1845
反应条件
1: sulfuric acid / 0.25 h / 130 °C / |Microwave irradiation 2: hydrazine hydrate / ethanol / 0.33 h / |Reflux 3: tetrahydrofuran / 0.13 h / 130 °C / |Microwave irradiation 4: sodium hydroxide / 0.05 h / 150 °C / |Microwave irradiation View Scheme
参考文献
Samanta, Sanjay; Lim, Ting Liang; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 6 p. 994 - 1001
反应条件
1: hydrazine hydrate / ethanol / 0.33 h / |Reflux 2: tetrahydrofuran / 0.13 h / 130 °C / |Microwave irradiation 3: sodium hydroxide / 0.05 h / 150 °C / |Microwave irradiation View Scheme
参考文献
Samanta, Sanjay; Lim, Ting Liang; Lam, Yulin
ChemMedChem, 2013 , vol. 8, # 6 p. 994 - 1001
反应条件
sodium hydroxide in ethanol Ambient temperature;
参考文献
Kane; Staeger; Dalton; Miller; Dudley; Ogden; Kehne; Ketteler; McCloskey; Senyah; Chmielewski
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 125 - 132
反应条件
1: in ethanol 0.5 h; Heating / reflux; 2: With MCPBA in dichloromethane T=20°C; 4 h; 3: With sodium hydrogencarbonate in dichloromethane; water; ethyl acetate
参考文献
WO2006/136223 A1, ;
Page/Page column 33 ;
WO 2006/136223 A1
