3,5-二溴对氨基苯磺酰胺合成路线 （共 12 条）
反应条件
bromine; CaBr2 in water T=25°C; 0.25 h; regioselective reaction;
参考文献
Kumar, Lalit; Mahajan, Tanu; Agarwal
Green Chemistry, 2011 , vol. 13, # 8 p. 2187 - 2196
反应条件
bromine; acetic acid
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1: chlorosulfonic acid / 4 h / 80 - 85 °C 2: aq. NH4OH / 0.5 h / 70 °C 3: aq. HCl / 0.75 h / Heating 4: aq. HBr; H2O2 / 2 h / 85 °C View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1: aq. HCl / 0.75 h / Heating 2: aq. HBr; H2O2 / 2 h / 85 °C View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1: 100 percent / 0.5 h / Heating 2: chlorosulfonic acid / 4 h / 80 - 85 °C 3: aq. NH4OH / 0.5 h / 70 °C 4: aq. HCl / 0.75 h / Heating 5: aq. HBr; H2O2 / 2 h / 85 °C View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1: aq. NH4OH / 0.5 h / 70 °C 2: aq. HCl / 0.75 h / Heating 3: aq. HBr; H2O2 / 2 h / 85 °C View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
参考文献
Fuchs
Monatshefte fuer Chemie, 1915 , vol. 36, p. 132
反应条件
sulfuric acid T=175 - 180°C; Darst. Beim Einleiten von Wasserdampf;
参考文献
Baliah, V.; Jeyanthy, J. Judith Diana
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1989 , vol. 28, # 6 p. 472 - 476
参考文献
Fuchs
Monatshefte fuer Chemie, 1915 , vol. 36, p. 132
参考文献
Wojahn
Archiv der Pharmazie (Weinheim, Germany), 1943 , vol. 281, p. 193,200
