2-氨基-5-叔丁基-1,3,4-噻二唑合成路线 （共 5 条）
参考文献
Hilfiker, Mark A.; Wang, Ning; Hou, Xiaoping; Du, Zhimin; Pullen, Mark A.; Nord, Melanie; Nagilla, Rakesh; Fries, Harvey E.; Wu, Charlene W.; Sulpizio, Anthony C.; Jaworski, Jon-Paul; Morrow, Dwight; Edwards, Richard M.; Jin, Jian
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4292 - 4295
参考文献
Matti et al.
Bulletin de la Societe Chimique de France, 1959 , p. 477
反应条件
triethylamine in ethyl acetate
参考文献
Bayer Aktiengesellschaft
Patent: US3981714 A1, 1976 ;
反应条件
1: pyridine / 1 h / 95 °C
2: hydrogenchloride / water / 0.5 h / Reflux
View Scheme
参考文献
Ahad, Ali Md.; Zuohe, Song; Du-Cuny, Lei; Moses, Sylvestor A.; Zhou, Li Li; Zhang, Shuxing; Powis, Garth; Meuillet, Emmanuelle J.; Mash, Eugene A.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2046 - 2054
反应条件
anschliessende Hydrolyse;
参考文献
Merck Index
9. Aufl. <Rahway, N.J. 1976> S. 4310
