2-氰基-2-吡啶-3-乙酸乙酯合成路线 (共 3 条)
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; palladium diacetate in 1,4-dioxane
T=70°C;
参考文献
Wang, Xiang; Guram, Anil; Bunel, Emilio; Cao, Guo-Qiang; Allen, Jennifer R.; Faul, Margaret M.
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1643 - 1645
反应条件
anhydrous 4,4'-bipyridyl; potassium hydroxide; potassium tert-butylate; potassium bromide in ammonia
T=-38°C; electrochemical synthesis, working electrode: platinum grid, constant current 200 mA;
参考文献
Amatore, Christian; Combellas, Catherine; Lebbar, Nour-Eddine; Thiebault, Andre; Verpeaux, Jean-Noel
Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 18 - 26
反应条件
sodium hydride; tetrakis(triphenylphosphine) palladium(0)
1.) DME, r.t., 10 min ; 2.) reflux, 6 h; Yield given. Multistep reaction;
参考文献
Sakamoto, Takao; Katoh, Eisaku; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 5 p. 1664 - 1668