5-甲基-5-己烯酸乙酯合成路线 （共 10 条）
反应条件
water T=160 - 170°C;
参考文献
KURARAY CO., LTD.
Patent: US2012/253062 A1, 2012 ;
Location in patent: Page/Page column 4 ;
反应条件
1: 50 percent / K2CO3 / dimethylformamide / 60 °C 2: 83 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Hendrickson, James B.; Boudreaux, Gerald J.; Palumbo, Paul S.
Journal of the American Chemical Society, 1986 , vol. 108, # 9 p. 2358 - 2366
反应条件
N,N-dioctyl-1-octylamine; water T=160 - 170°C; Product distribution / selectivity;
参考文献
KURARAY CO., LTD.
Patent: US2012/253062 A1, 2012 ;
Location in patent: Page/Page column 3 ;
反应条件
aluminium trichloride in benzene
参考文献
Beckwith,A.L.J.; Moad,G.
Australian Journal of Chemistry, 1977 , vol. 30, p. 2733 - 2739
反应条件
1.1: sodium ethanolate / ethanol / 60 °C 1.2: 80 °C 2.1: N,N-dioctyl-1-octylamine; water / 160 - 170 °C View Scheme
参考文献
KURARAY CO., LTD.
Patent: US2012/253062 A1, 2012 ;
反应条件
1.1: triethylamine / toluene / 5 - 20 °C 2.1: sodium ethanolate / ethanol / 60 °C 2.2: 80 °C 3.1: N,N-dioctyl-1-octylamine; water / 160 - 170 °C View Scheme
参考文献
KURARAY CO., LTD.
Patent: US2012/253062 A1, 2012 ;
反应条件
1.1: triethylamine / toluene / 5 - 20 °C 2.1: sodium ethanolate / ethanol / 60 °C 2.2: 80 °C 3.1: water / 160 - 170 °C View Scheme
参考文献
KURARAY CO., LTD.
Patent: US2012/253062 A1, 2012 ;
反应条件
(i) NaH, (ii) /BRN= 1718733/, N,N'-carbonyldiimidazole; Multistep reaction;
参考文献
Comer,W.T.; Temple,D.L.
Journal of Organic Chemistry, 1973 , vol. 38, # 12 p. 2121 - 2125
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / Heating
1.2: 45 percent / tetrahydrofuran; hexane / 20 °C
2.1: 80 percent / KOH / acetone / 20 °C
View Scheme
参考文献
Liu, Cong; Han, Xiaoqing; Wang, Xiang; Widenhoefer, Ross A.
Journal of the American Chemical Society, 2004 , vol. 126, # 12 p. 3700 - 3701
反应条件
1: ortho-N-trimethylsilyl-toluidine With n-butyllithium in tetrahydrofuran; hexane
Heating;
2: ethyl 5-methyl-hex-5-enoate in tetrahydrofuran; hexane
T=20°C;
参考文献
Liu, Cong; Han, Xiaoqing; Wang, Xiang; Widenhoefer, Ross A.
Journal of the American Chemical Society, 2004 , vol. 126, # 12 p. 3700 - 3701
