4-(4-氯苯基)-4-羟基哌啶合成路线 （共 28 条）
反应条件
1: sodium iodide; sodium carbonate / acetonitrile / |Reflux
2: potassium hydroxide; tert-butyl alcohol / 48 h / |Reflux
View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5259 - 5263
反应条件
formaldehyd; conc. ammonia in acetic acid
参考文献
John Wyeth and Brother Limited
Patent: US4358456 A1, 1982 ;
参考文献
Vangveravong, Suwanna; McElveen, Elizabeth; Taylor, Michelle; Xu, Jinbin; Tu, Zhude; Luedtke, Robert R.; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 815 - 825
反应条件
acetic acid in ethanol
5 h; Heating;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
piperidine in ethanol
7 h; Heating;
参考文献
Kreutzberger
Archiv der Pharmazie, 1984 , vol. 317, # 5 p. 417 - 420
反应条件
sodium cyanoborohydride; acetic acid in methanol
T=20°C; 30 h;
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
T=100°C; 17.5 h;
参考文献
Moerlein, Stephen M.; Stoecklin, Gerhard L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1319 - 1324
反应条件
in methanol; ethanol; chloroform
3 h; Ambient temperature;
参考文献
Hirai, Kentaro; Ishiba, Teruyuki; Sugimoto, Hirohiko; Fujishita, Toshio; Tsukinoki, Yuji; Hirose, Katsumi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 20 - 27
