5-甲氧基-3-苯并呋喃酮合成路线 （共 16 条）
反应条件
1: With sodium acetate; acetic anhydride T=150°C; 4 h; 2: With hydrogenchloride; water 2 h; Heating / reflux;
参考文献
Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Gu, Yansong
Patent: US2005/4162 A1, 2005 ;
Location in patent: Page/Page column 17 ;
US 20050004162 A1
反应条件
sodium acetate in ethanol 2 h; Reflux;
参考文献
Cheng, Huimin; Zhang, Lianwen; Liu, Yingxue; Chen, Shaopeng; Cheng, Hao; Lu, Xin; Zheng, Zhuxia; Zhou, Guo-Chun
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5950 - 5957
反应条件
1: With hydrogenchloride; AlCl3, aluminium chloride in anhydrous dichloroethane; water T=0 - 35°C; Friedel Crafts Acylation; 3.5 h; 2: With sodium acetate in methanol 1.5 h; Heating / reflux;
参考文献
FERRER INTERNACIONAL, S.A.
Patent: WO2009/53444 A1, 2009 ;
Location in patent: Page/Page column 12-13 ;
WO 2009/053444 A1
反应条件
PPA T=75°C; 0.833333 h;
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.
Patent: WO2003/93258 A2, 2003 ;
Location in patent: Page/Page column 18 ;
反应条件
hydrogenchloride; water in methanol 5 h; Reflux;
参考文献
Ono, Masahiro; Ikeoka, Ryoichi; Watanabe, Hiroyuki; Kimura, Hiroyuki; Fuchigami, Takeshi; Haratake, Mamoru; Saji, Hideo; Nakayama, Morio
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5743 - 5748
反应条件
potassium carbonate in acetone T=20°C; Inert atmosphere;
参考文献
Kim, Yongju; Kim, Jonghoon; Park, Seung Bum
Organic Letters, 2009 , vol. 11, # 1 p. 17 - 20
反应条件
1: diethyl ether 2: gl. AcOH / 1.5 h View Scheme
参考文献
Tomaszewski, Zbigniew; Johnson, Michael P.; Huang, Xuemei; Nichols, David E.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2061 - 2064
反应条件
1: 97 percent / oxalyl chloride, DMF / benzene / 2.5 h 2: diethyl ether 3: gl. AcOH / 1.5 h View Scheme
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Lewis, Mechelle M.; Mailman, Richard B.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 12 p. 2134 - 2145
反应条件
1: BCl3, AlCl3 / CH2Cl2; 1,2-dichloro-ethane / 2.5 h 2: AcONa / methanol / 1.5 h / Heating View Scheme
参考文献
Hammond, Milton L.; Zambias, Robert A.; Chang, Michael N.; Jensen, Norman P.; McDonald, John; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 909 - 918
反应条件
1: 71 percent / xylene / 72 h / Heating 2: 98 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating 3: 82.5 percent / triphenyl phosphine, diethyl azodicarboxylate / tetrahydrofuran / 1 h / Ambient temperature 4: 51 percent / hydrazine hydrate / ethanol / 3 h / Heating View Scheme
参考文献
Tomaszewski, Zbigniew; Johnson, Michael P.; Huang, Xuemei; Nichols, David E.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2061 - 2064
