N-苄氧羰基-N-甲基甘氨酸合成路线 （共 19 条）
反应条件
1: With camphor-10-sulfonic acid 15 h; Heating; 2: With diisobutylaluminium hydride in hexane; dichloromethane T=-78°C; 2 h;
参考文献
Tietze, Lutz F.
Angewandte Chemie - International Edition, 2001 , vol. 40, # 5 p. 903 - 905
反应条件
(i) DCC, (ii) aq. NaOH; Multistep reaction;
参考文献
Okada; Iguchi; Okinaka; Yagyu; Sano; Otani
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 11 p. 3588 - 3591
反应条件
(i) DCC, (ii) CF3CO2H; Multistep reaction;
参考文献
Titlestad,K.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1977 , vol. 31, p. 641 - 661
反应条件
1: N-benzyloxycarbonyl-N-methylglycine With 4-methyl-morpholine; chloroformic acid ethyl ester in tetrahydrofuran
T=-15°C; 0.25 h;
2: diazomethane in tetrahydrofuran; dichloromethane
T=-15 - 20°C;
参考文献
Hughes, Andrew B.; Sleebs, Brad E.
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2611 - 2637
反应条件
dicyclohexyl-carbodiimide in ethylene glycol dimethyl ether
T=0°C;
参考文献
Atherton; Hassall; Lambert
Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 29 - 40
反应条件
diethyl ether; phosphorus tribromide
参考文献
Ben-Ishai; Katchalski
Journal of the American Chemical Society, 1952 , vol. 74, p. 3688
反应条件
sulfuric acid in dichloromethane
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4604402 A1, 1986 ;
US 4604402 A
反应条件
(i) DCC, (ii) aq. NaOH; Multistep reaction;
参考文献
Titlestad,K.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1975 , vol. 29, p. 153 - 167
反应条件
dicyclohexyl-carbodiimide in dichloromethane
参考文献
Tanaka, Takumi; Nakajima, Kiichiro; Okawa, Kenji
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 5 p. 1351 - 1355
