4-(氯甲基)苯基乙酸酯合成路线 （共 11 条）
反应条件
1: ethylene dibromide; zinc With lithium chloride in tetrahydrofuran
Heating;
2: acetic acid 4-chloromethyl-phenyl ester in tetrahydrofuran
Heating;
3: monobromoacetic acid chloride; C8H7ClO2Zn With Li2Cu(CN)Cl2 in tetrahydrofuran
T=-80 - 25°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Mosrin, Marc; Bresser, Tomke; Knochel, Paul
Organic Letters, 2009 , vol. 11, # 15 p. 3406 - 3409
