2,3,11,12-dicyclohexano-1,4,7,10,13,16-hexaoxacyclo-octadecane in diethylene glycol dimethyl ether 3 h; Ambient temperature;

triethylamine in dichloromethane T=-20 - 20°C; 6 h;

1: 1-(methanesulfonyl)piperidine With zinc(II) chloride; lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 20°C; 1 h; Inert atmosphere; 2: bromobenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=20 - 65°C; Negishi coupling reaction; Inert atmosphere;

1: 1-(methanesulfonyl)piperidine With zinc(II) chloride; lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 20°C; 1 h; Inert atmosphere; 2: iodobenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=20 - 65°C; Negishi coupling reaction; Inert atmosphere;

1: 1-(methanesulfonyl)piperidine With zinc(II) chloride; lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 20°C; 1 h; Inert atmosphere; 2: trifluoromethanesulfonyloxybenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=20 - 65°C; Negishi coupling reaction; Inert atmosphere;

acetyl chloride