N-羟基-7-氮杂苯并三氮唑合成路线 （共 10 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 16 h;
参考文献
Sin, Ny; Good, Andrew Charles; Venables, Brian Lee; Scola, Paul Michael; Meanwell, Nicholas A.
Patent: US2006/183694 A1, 2006 ;
Location in patent: Page/Page column 47-48 ;
US 20060183694 A1
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl acetamide T=20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/32086 A1, 2008 ;
Location in patent: Page/Page column 120-121 ;
WO 2008/032086 A1
反应条件
hydrazine hydrate Heating;
参考文献
Williamson, David A.; Bowler, Bruce E.
Tetrahedron, 1996 , vol. 52, # 38 p. 12357 - 12372
反应条件
in chloroform; N,N-dimethyl-formamide T=20°C; Methylation;
参考文献
Carpino, Louis A.; Imazumi, Hideko; Foxman, Bruce M.; Vela, Michael J.; Henklein, Peter; El-Faham, Ayman; Klose, Jana; Bienert, Michael
Organic Letters, 2000 , vol. 2, # 15 p. 2253 - 2256
反应条件
1: 90.9 percent / KOH / dimethylsulfoxide / 0.33 h 2: 25.9 percent / aq. N2H4 / Heating View Scheme
参考文献
Hoeg-Jensen, Thomas; Holm, Arne; Sorensen, Hilmer
Synthesis, 1996 , # 3 p. 383 - 387
反应条件
hydrazine hydrate in ethanol 24 h; Reflux;
参考文献
Fathalla, Magda Fouad; Khattab, Sherine Nabil
Journal of the Chemical Society of Pakistan, 2011 , vol. 33, # 3 p. 324 - 332
反应条件
benzenethiol sodium salt in dimethylsulfoxide-d6; chloroform-d1 demethylation; Kinetics; Further Variations:Solvents;
参考文献
Carpino, Louis A.; Imazumi, Hideko; Foxman, Bruce M.; Vela, Michael J.; Henklein, Peter; El-Faham, Ayman; Klose, Jana; Bienert, Michael
Organic Letters, 2000 , vol. 2, # 15 p. 2253 - 2256
反应条件
in acetonitrile T=30°C; Kinetics; Further Variations:Temperatures;
参考文献
Khattab, Sherine Nabil; Hassan, Seham Yassin; Hamed, Ezzat Awad; Albericio, Fernando; Ayman, El-Faham
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 1 p. 75 - 81
反应条件
in acetonitrile T=30°C; Kinetics; Temperature;
参考文献
Khattab, Sherine Nabil; Hassan, Seham Yassin; Hamed, Ezzat Awad; Albericio, Fernando; Ayman, El-Faham
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 1 p. 75 - 81
反应条件
potassium carbonate in acetone
Methylation;
参考文献
Carpino, Louis A.; Imazumi, Hideko; Foxman, Bruce M.; Vela, Michael J.; Henklein, Peter; El-Faham, Ayman; Klose, Jana; Bienert, Michael
Organic Letters, 2000 , vol. 2, # 15 p. 2253 - 2256
