1: (methoxymethyl)-triphenylphosphonium chloride With phenyllithium in tetrahydrofuran T=0°C; Dehydrochlorination; 0.166667 h; 2: 2-methoxy 5-cyanobenzene in tetrahydrofuran T=20°C; Alkylation; 2 h; 3: With water in tetrahydrofuran Hydrolysis;
1: (methoxymethyl)-triphenylphosphonium chloride With potassium tert-butylate in tetrahydrofuran T=0°C; 0.5 h; 2: 4-bromo-benzaldehyde in tetrahydrofuran T=20°C; 46 h;
参考文献
Van Der Pijl, Ferdi; Harmel, Robert K.; Richelle, Gaston J. J.; Janssen, Peter; Van Delft, Floris L.; Rutjes, Floris P. J. T.
Organic Letters, 2014 , vol. 16, # 7 p. 2038 - 2041
1: (methoxymethyl)-triphenylphosphonium chloride With potassium tert-butylate in tetrahydrofuran T=0°C; 0.5 h; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran T=20°C; 12 h; 3: With formic acid in dichloromethane T=20°C; 72 h; Further stages.;
参考文献
Pedrosa; Andres; Iglesias
Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 243 - 250
