potassium 2-methyl-2-butoxide in tetrahydrofuran
Ambient temperature;
参考文献
Srikrishna, Adusumilli; Nagaraju, Sankuratri; Sharma, G. Veera Raghava
Journal of the Chemical Society, Chemical Communications, 1993 , # 3 p. 285 - 288
1: (methoxymethyl)-triphenylphosphonium chloride With sodium hydride in tetrahydrofuran; mineral oil
T=0°C; 0.666667 h;
2: 1-(1,1-diphenylmethyl)azetidin-3-one in tetrahydrofuran; mineral oil
T=0°C; 2 h; Heating / reflux;
参考文献
WYETH
Patent: WO2004/24730 A1, 2004 ;
Location in patent: Page 47 ;
WO 2004/024730 A1
1: (methoxymethyl)-triphenylphosphonium chloride With n-butyllithium in tetrahydrofuran
T=-50 - -25°C; 0.5 h;
2: 3-benzyl-3-azabicyclo[3.2.1]octan-8-one in tetrahydrofuran
T=-25 - 20°C;
3: With hydrogenchloride; sodium hydroxide; water
more than 3 stages;
1: (methoxymethyl)-triphenylphosphonium chloride With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 1 h;
2: Spirolt;cyclopropane-3'-norbornangt;-2'-one in tetrahydrofuran; hexane
T=0 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
T=20°C; 3 h;
n-butyllithium in tetrahydrofuran; hexane
15 h; Ambient temperature; Yield given;
参考文献
Thompson, Ambler; Lever, John R.; Canella, Karen A.; Miura, Kyo; Posner, Gary H.; Seliger, H. H.
Journal of the American Chemical Society, 1986 , vol. 108, # 15 p. 4498 - 4504
