反应条件
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere 2.1: iron acetylacetonate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / -30 - 0 °C / Inert atmosphere 2.2: 0.25 h / 10 - 35 °C / pH 0 - 1 / Inert atmosphere 3.1: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 20 °C / Inert atmosphere 3.2: 1 h / 20 °C / Inert atmosphere 4.1: hydrogenchloride; hydrogen / 2-5percent w/w palladium on carbon / water; methanol / 20 - 30 °C / Inert atmosphere View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; MUKHTAR, Sayeed; NAIR, Dinesh, Shashidharan; MEDHANE, Roshan, Ramesh; MAHESHWARI, Nitin; MEERAN, Hashim, Nizar, Poovanathil, Nagoor; TEWARI, Neera; PRASAD, Mohan
Patent: WO2011/33473 A1, 2011 ;
