1: (R)-(-)-1-phenyl-2-(piperidin-1-yl)ethanol With methanesulfonyl chloride; triethylamine in diethyl ether 0.5 h; 2: 2,2-dimethyl-1-propylamine With water; triethylamine in diethyl ether T=20°C; 16 h;

1: (R)-(-)-1-phenyl-2-(piperidin-1-yl)ethanol With methanesulfonyl chloride; triethylamine in diethyl ether 0.5 h; 2: isopropylamine With water; triethylamine in diethyl ether T=20°C; 16 h; Title compound not separated from byproducts;

1: (R)-(-)-1-phenyl-2-(piperidin-1-yl)ethanol With methanesulfonyl chloride; triethylamine in diethyl ether 0.5 h; 2: 1,3-diamino-propane With water; triethylamine in diethyl ether T=20°C; 16 h;

1: triethylamine / diethyl ether / 30 h / Ambient temperature 2: H2O; diethyl ether / 12 h / Ambient temperature View Scheme

With  [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; bis[2-(diphenylphosphino)phenyl] ether T=115°C; 1.5 h;  Inert atmosphereMicrowave irradiationNeat (no solvent);   

Multi-step reaction with 2 steps 1: 95 percent / benzene / 1 h / 0 °C2: 88 percent / LiAlH4 / diethyl ether / 0.5 h / 20 °C