2-羟基-3,3-二甲基丁酸合成路线 （共 34 条）
参考文献
Richard
Annales de Chimie (Cachan, France), 1910 , vol. <8> 21, p. 394
参考文献
Schindler
Monatshefte fuer Chemie, 1892 , vol. 13, p. 648
参考文献
Schindler
Monatshefte fuer Chemie, 1892 , vol. 13, p. 648
反应条件
Bi(NO3)3; sodium hydroxide; oxygen; palladium on activated carbon in water T=95°C; 2 h;
参考文献
US2004/30186 A1, ;
Page 3-4 ;
参考文献
Schindler
Monatshefte fuer Chemie, 1892 , vol. 13, p. 648
反应条件
Bi(NO3)3; sodium hydroxide; oxygen; palladium on activated carbon in water T=65 - 102.5°C; 0.7 - 19 h;
参考文献
Fiege, Helmut
Patent: US2004/30186 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
Bi(NO3)3; sodium hydroxide; oxygen; palladium on activated carbon in water T=95°C; 2 h;
参考文献
US2004/30186 A1, ;
Page 3-4 ;
反应条件
1.1: acetyl chloride / 4 h / 65 °C / |Inert atmosphere; |Schlenk technique 2.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 0 °C / |Inert atmosphere; |Schlenk technique 2.2: 3 h / 0 - 20 °C / |Inert atmosphere; |Schlenk technique 3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C / |Inert atmosphere; |Schlenk technique 4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / |Inert atmosphere; |Schlenk technique 4.2: 1 h / -78 - 20 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Nitsch, Dominik; Huber, Stefan M.; Poethig, Alexander; Narayanan, Arjun; Olah, George A.; Prakash, G. K. Surya; Bach, Thorsten
Journal of the American Chemical Society, 2014 , vol. 136, # 7 p. 2851 - 2857
反应条件
1: With sodium tetrahydroborate; sodium hydroxide in water
T=0 - 20°C; 16.5 h; Inert atmosphereSchlenk technique;
2: With hydrogenchloride in water
Inert atmosphereSchlenk technique;
参考文献
Nitsch, Dominik; Huber, Stefan M.; Poethig, Alexander; Narayanan, Arjun; Olah, George A.; Prakash, G. K. Surya; Bach, Thorsten
Journal of the American Chemical Society, 2014 , vol. 136, # 7 p. 2851 - 2857
反应条件
hydrogenchloride in water
T=20°C; 20 h; Reflux;
参考文献
Robertson, Jeremy; Hall, Michael J.; Green, Stuart P.
Tetrahedron, 2009 , vol. 65, # 28 p. 5541 - 5551
