2-羟基-3,3-二甲基丁酸合成路线 （共 34 条）
反应条件
1: 35percent H2SO4 / H2O / 0.5 h / Ambient temperature
2: 91 percent / conc. HCl / 1.) room temp., 10 h 2.) reflux, 4 h
View Scheme
参考文献
Hartwig; Schollkopf
1982 , vol. No. 11, p. 1952 - 1970
参考文献
Wittorf
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1900 , vol. 32, p. 112
Chem. Zentralbl., 1900 , vol. 71, # II p. 29
参考文献
Gripenberg; Silander
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 383,384,385,388
反应条件
potassium hydroxide in water
T=0°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Reeve, Wilkins; McKee, James R.; Brown, Robert; Lakshmanan, Sitarama; McKee, Gertrude A.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 485 - 493
反应条件
piperidine
in mehrere Stufen;
参考文献
Richard
Annales de Chimie (Cachan, France), 1910 , vol. <8> 21, p. 394
参考文献
Jegorowa
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1909 , vol. 41, p. 1460
Chem. Zentralbl., 1910 , vol. 81, # I p. 1003
反应条件
1: BaCO3; water
2: alkaline copper / 75 - 90 °C
View Scheme
参考文献
Faworski
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1912 , vol. 44, p. 1370
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 88, p. 672
反应条件
sodium hypobromide; water
参考文献
Richard; Langlais
Bulletin de la Societe Chimique de France, 1910 , vol. <4>7, p. 465
参考文献
Knoop; Oesterlin
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1925 , vol. 148, p. 311
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1927 , vol. 170, p. 187,195
参考文献
Poggi
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 334,339
Gazzetta Chimica Italiana, 1947 , vol. 77, p. 540
