4-氟-3-甲基-苯甲酸合成路线 （共 17 条）
参考文献
Schiemann; Roselius
Chemische Berichte, 1932 , vol. 65, p. 737,742
反应条件
1: With potassium permanganate in water 24 h; Heating / reflux; 2: With hydrogenchloride in water T=20°C; Heating;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2004/113281 A1, 2004 ;
Location in patent: Page 63 ;
反应条件
thionyl chloride 1 h; Heating / reflux;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2005/203078 A1, 2005 ;
Location in patent: Page/Page column 42 ;
反应条件
hydrogenchloride in water 4 h; Reflux;
参考文献
Bolin, David Robert; Hayden, Stuart; Qian, Yimin; Thakkar, Kshitij Chhabilbhai
Patent: US2011/136792 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=25°C; 15 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40568 A1, 2006 ;
Location in patent: Page/Page column 61 ;
WO 2006/040568 A1
反应条件
sulfuric acid in methanol 4 h; Heating / reflux;
参考文献
ASTELLAS PHARMA INC.; WAKUNAGA PHARMACEUTICAL CO., LTD.
Patent: WO2006/38734 A1, 2006 ;
Location in patent: Page/Page column 50 ;
反应条件
1: thionyl chloride; N,N-dimethylformamide / 2 h / Heating
2: 79 percent / AlCl3 / 1 h / Heating
3: 65 percent / Heating
View Scheme
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.; Horton, Peter N.; Hursthouse, Michael B.
Tetrahedron, 2005 , vol. 61, # 2 p. 463 - 471
