2-溴-4'-氟苯乙酮合成路线 （共 119 条）
参考文献
Bahner et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 3960
反应条件
sodium carbonate; 1-butylpyridinium tetrafluoroborate
T=20°C; Chichibabin cyclocondensation; 3 h;
参考文献
Xu, Danqian; Liu, Baoyou; Zheng, Mei
Journal of Chemical Research - Part S, 2003 , # 10 p. 645 - 647
反应条件
in N,N-dimethyl-formamide
T=120°C; 0.333333 h; microwave irradiation;
参考文献
Xiang, Jason; Ipek, Manus; Suri, Vipin; Tam, May; Xing, Yuzhe; Huang, Nelson; Zhang, Yanling; Tobin, James; Mansour, Tarek S.; McKew, John
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4396 - 4405
反应条件
1: 1.) THF, RT, 1 h, 2.) THF, RT, 2 h
2: aq. NaOCl / CHCl3 / 0.5 h / Ambient temperature
View Scheme
参考文献
Yuan, Chengye; Xie, Rongyuan
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 90, # 1-4 p. 47 - 52
参考文献
Baboulene,M. et al.
Chimica Therapeutica, 1972 , vol. 7, p. 493 - 502
反应条件
1: N,N-dimethyl-formamide
2: hydrogen bromide; acetic acid / water
View Scheme
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
反应条件
1.1: triethylamine / toluene / 20 °C
2.1: methanol; water / 1 h / 20 °C
2.2: 20 °C / pH 7 - 8
3.1: dichloromethane / Reflux; Inert atmosphere
View Scheme
参考文献
An, Xiao-Lei; Chen, Jia-Rong; Li, Chang-Feng; Zhang, Fu-Gen; Zou, You-Quan; Guo, Ying-Cen; Xiao, Wen-Jing
Chemistry - An Asian Journal, 2010 , vol. 5, # 10 p. 2258 - 2265
参考文献
Sturz, G.; Clement, J. C.; Daniel, A.; Molinier, J.; Lenzi, M.
Bulletin de la Societe Chimique de France, 1981 , vol. 1, # 5-6 p. 161 - 172
反应条件
formic acid
3.5 h; Heating / reflux;
参考文献
Pfizer Inc.
Patent: US2003/225056 A1, 2003 ;
Location in patent: Page 42 ;
