2-(4-硝基苯基)丙二酸二甲酯合成路线 （共 5 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=70°C; 16 h;
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; LESCH, Bernhard; BAHRENBERG, Gregor; SAUNDERS, Derek John; STOCKHAUSEN, Hannelore; KIM, Yong-Soo; KIM, Myeong-Seop; LEE, Jeewoo
Patent: WO2013/68461 A1, 2013 ;
Location in patent: Page/Page column 141 ;
反应条件
potassium phosphate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; palladium diacetate in 1,4-dioxane T=90°C; 8 h;
参考文献
SANOFI-AVENTIS
Patent: US2009/215728 A1, 2009 ;
Location in patent: Page/Page column 76 ;
US 20090215728 A1
反应条件
1: 55 percent / NaH / 20 °C 2: 61 percent / NaCl / dimethylsulfoxide; H2O / 155 °C View Scheme
参考文献
Selvakumar; Yadi Reddy; Sunil Kumar; Iqbal, Javed
Tetrahedron Letters, 2001 , vol. 42, # 47 p. 8395 - 8398
参考文献
Basterfield; Hamilton
Trans. roy. Soc. Canada, 1933 , vol. <3> 27 III, p. 125,128
反应条件
sodium tetrahydroborate; bromine in ethylene glycol dimethyl ether
T=0 - 20°C; 4 h;
参考文献
Tudge, Matthew; Mashima, Hiroko; Savarin, Cecile; Humphrey, Guy; Davies, Ian
Tetrahedron Letters, 2008 , vol. 49, # 6 p. 1041 - 1044
