1-氟-4-苯基乙炔-苯合成路线 （共 39 条）
反应条件
1: SPHOS; tris-(dibenzylideneacetone)dipalladium(0); tetra-n-butylammonium fluoride trihydrate / 1-methyl-pyrrolidin-2-one; water / 4 h / 50 °C
2: 1-methyl-pyrrolidin-2-one / 14 h / 80 °C
View Scheme
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
1: SPHOS; bis(η3-allyl-μ-chloropalladium(II)); tetra-n-butylammonium fluoride trihydrate / 1-methyl-pyrrolidin-2-one; water / 16 h / 50 °C / Inert atmosphere
2: 1-methyl-pyrrolidin-2-one / 14 h / 80 °C
View Scheme
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
in 1-methyl-pyrrolidin-2-one
T=80°C; 14 h;
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
Gascoyne,J.M. et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977 , p. 1051 - 1057
参考文献
Rooney; Bourns
Canadian Journal of Chemistry, 1955 , vol. 33, p. 1633,1636
反应条件
ethanol; nickel
Hydrogenation;
参考文献
Rooney; Bourns
Canadian Journal of Chemistry, 1955 , vol. 33, p. 1633,1636
反应条件
palladium dichloride in chlorobenzene
Reflux;
参考文献
Xie, Hou-Zhi; Gao, Qi; Liang, Ying; Wang, Heng-Shan; Pan, Ying-Ming
Green Chemistry, 2014 , vol. 16, # 4 p. 2132 - 2135
反应条件
palladium dichloride in chlorobenzene
4 h; Reflux; Overall yield = 90 percent;
参考文献
Xie, Hou-Zhi; Gao, Qi; Liang, Ying; Wang, Heng-Shan; Pan, Ying-Ming
Green Chemistry, 2014 , vol. 16, # 4 p. 2132 - 2135
