(三甲基硅基)乙酸乙酯合成路线 （共 118 条）
反应条件
BTAF
240 h; Ambient temperature;
参考文献
Nakamura, Eiichi; Hashimoto, Koichi; Kuwajima, Isao
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 3 p. 805 - 808
反应条件
t-Bu-N=P[N=P(NMe2)3]3 in tetrahydrofuran; hexane
T=-78°C; Peterson olefination; 6 h;
参考文献
Kobayashi, Koji; Ueno, Masahiro; Kondo, Yoshinori
Chemical Communications, 2006 , # 29 p. 3128 - 3130
反应条件
1: With Verkade’s superbase in tetrahydrofuran
T=20°C; Peterson olefination; 24 h; Inert atmosphere;
2: With hydrogenchloride in tetrahydrofuran; water
T=20°C; Peterson olefination; 1 h; Inert atmosphere; stereoselective reaction;
参考文献
Wadhwa, Kuldeep; Verkade, John G.
Journal of Organic Chemistry, 2009 , vol. 74, # 11 p. 4368 - 4371
反应条件
lithium diisopropyl amide
1.) THF, hexane, -78 deg C, 1 h, 2.) a) from -78 deg C to room temp., 1 h, b) room temp., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tsuge, Otohiko; Sone, Kazuhiro; Urano, Satoshi; Matsuda, Koyo
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5171 - 5177
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 2 h;
参考文献
CYTOCHROMA INC.; JOHNS HOPKINS UNIVERSITY; POSNER, Gary, H.; HESS, Lindsey, C.; KALINDA, Alvin, S.; SLACK, Rachel, D.; SAHA, Uttam; PETKOVICH, P., Martin
Patent: WO2011/88209 A2, 2011 ;
Location in patent: Page/Page column 59-60 ;
反应条件
tetrabutylammonium fluoride absorbed on silica gel in tetrahydrofuran
6.5 h; Ambient temperature;
参考文献
Gambacorta, Augusto; Turchetta, Stefano; Botta, Maurizio
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2441 - 2448
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
参考文献
Dicker, Ira B.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2324 - 2327
反应条件
sulfuric acid
1.)ethyl trimethylsilylacetate, ether, -78 grad C, warmed to rt., stirred overnight, 2.) THF/conc. H2SO4, 15 h; Yield given. Multistep reaction;
参考文献
Larson, Gerald L.; Hernandez, David
Tetrahedron Letters, 1982 , vol. 23, # 10 p. 1035 - 1038
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Nakamura,E. et al.
Journal of the American Chemical Society, 1976 , vol. 98, p. 2346 - 2348
反应条件
LiN(Cy)2
1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to 25 deg C, 4.5 h; Yield given. Multistep reaction;
参考文献
Patel; Vyas; Pandey; Tavares; Fernandes
Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1935 - 1940
