2-甲氧基-5-硝基苯甲酸合成路线 （共 33 条）
参考文献
Chattaway; Farinholt
Journal of the Chemical Society, 1931 , p. 1828,1833
参考文献
Chattaway; Calvet
Journal of the Chemical Society, 1928 , p. 2917
参考文献
Hill; Hale
American Chemical Journal, 1905 , vol. 33, p. 10
参考文献
Pohlmann
Recueil des Travaux Chimiques des Pays-Bas, 1936 , vol. 55, p. 737,740
反应条件
1: 2-methoxy-5-nitrobenzoic acid With potassium carbonate in N,N-dimethyl-formamide T=80°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide T=80°C;
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/186692 A1, 2013 ;
Location in patent: Page/Page column 67 ;
反应条件
hydrogenchloride; tin
参考文献
Kuechler and Buff
Patent: DE71258 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 838
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 1.2: 80 °C 2.1: palladium 10 on activated carbon; hydrogen / methanol / 3620.13 - 4137.29 Torr View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/186692 A1, 2013 ;
反应条件
1: Et3N / CH2Cl2 / -10 °C 2: CH2Cl2 / -10 - 20 °C 3: H2 / Pd/C / tetrahydrofuran; ethanol / 2207.43 Torr View Scheme
参考文献
Nomura, Masahiro; Tanase, Takahiro; Ide, Tomohiro; Tsunoda, Masaki; Suzuki, Masahiro; Uchiki, Hideharu; Murakami, Koji; Miyachi, Hiroyuki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 17 p. 3581 - 3599
反应条件
1: SOCl2 / 1 h / Heating
2: Et3N / CH2Cl2 / 0.25 h / Ambient temperature
3: 35 percent / Sn, HCl aq. / 4 h / 50 °C
4: 57 percent / Et3N / CH2Cl2 / 0.25 h
View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shiomi, Teruo; Eigyo, Masami; Hirose, Katsumi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1137 - 1141
反应条件
thionyl chloride
4 h; Heating / reflux;
参考文献
McGinley, John; McKee, Vickie; Walsh, John M.D.
Inorganica Chimica Acta, 2011 , vol. 375, # 1 p. 57 - 62
