3-(1H-吡咯-2-基)丙酸合成路线 （共 10 条）
反应条件
water; sodium hydroxide in ethanol T=0 - 20°C;
参考文献
PONIARD PHARMACEUTICALS, INC.
Patent: WO2009/139834 A1, 2009 ;
Location in patent: Page/Page column 161 ;
反应条件
1: H2 / Pd/C / methanol / 6 h 2: K2CO3 / H2O; ethanol / Heating View Scheme
参考文献
PONIARD PHARMACEUTICALS, INC.
Patent: WO2009/139834 A1, 2009 ;
反应条件
hydrogenchloride; potassium hydroxide; N-benzyl-trimethylammonium hydroxide
参考文献
Air Products and Chemicals, Inc.
Patent: US5512603 A1, 1996 ;
反应条件
1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere 2: hydrogen / palladium on carbon / methanol / 20 °C 3: sodium hydroxide; water / ethanol / 0 - 20 °C View Scheme
参考文献
PONIARD PHARMACEUTICALS, INC.
Patent: WO2009/139834 A1, 2009 ;
反应条件
potassium hydroxide T=100°C; Erhitzen des Reaktionsprodukts mit Kupfer-Pulver auf 140-160grad/80-100 Torr;
参考文献
Kutscher; Klamerth
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1952 , vol. 289, p. 229,231
反应条件
1: Raney nickel; methanol / Hydrogenation 2: methanol. KOH / 100 °C / Erhitzen des Reaktionsprodukts mit Kupfer-Pulver auf 140-160grad/80-100 Torr View Scheme
参考文献
Kutscher; Klamerth
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1952 , vol. 289, p. 229,231
参考文献
Harley-Mason
Journal of the Chemical Society, 1952 , p. 2433
参考文献
Kutscher; Klamerth
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1952 , vol. 289, p. 229,231
反应条件
1.1: N-methylmorpholine; ClCO2Et / diethyl ether / 0.25 h / 0 °C 1.2: 70 percent / diethyl ether / 0 - 20 °C 2.1: 30 percent / Rh2(OAc)4 / CH2Cl2 / 20 °C View Scheme
参考文献
Cuevas-Yanez, Erick; Muchowski, Joseph M.; Cruz-Almanza, Raymundo
Tetrahedron, 2004 , vol. 60, # 7 p. 1505 - 1511
反应条件
pyridine; dicyclohexyl-carbodiimide in ethyl acetate
T=20°C;
参考文献
Malan, Sarel F.; Marle, Andre Van; Menge, Wiro M.; Zuliana, Valentina; Hoffman, Marcel; Timmerman, Henk; Leurs, Rob
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6495 - 6503
