2-(乙酰氧基)苯甲酸4-(氯甲基)苯基酯合成路线 （共 4 条）
反应条件
thionyl chloride T=0 - 20°C; 2 h;
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
1: SOCl2; pyridine / CH2Cl2 / 2 h / 0 °C 2: 3.71 g / Et3N / CH2Cl2 / 2 h / 0 °C 3: 76 percent / NaBH4 / tetrahydrofuran / 1.33 h / 0 °C 4: SOCl2; pyridine / CH2Cl2 / 4.75 h / -30 - 20 °C View Scheme
参考文献
Chiroli, Valerio; Benedini, Francesca; Ongini, Ennio; Del Soldato, Piero
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 441 - 446
反应条件
1: 76 percent / NaBH4 / tetrahydrofuran / 1.33 h / 0 °C 2: SOCl2; pyridine / CH2Cl2 / 4.75 h / -30 - 20 °C View Scheme
参考文献
Chiroli, Valerio; Benedini, Francesca; Ongini, Ennio; Del Soldato, Piero
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 441 - 446
反应条件
1: 3.71 g / Et3N / CH2Cl2 / 2 h / 0 °C 2: 76 percent / NaBH4 / tetrahydrofuran / 1.33 h / 0 °C 3: SOCl2; pyridine / CH2Cl2 / 4.75 h / -30 - 20 °C View Scheme
参考文献
Chiroli, Valerio; Benedini, Francesca; Ongini, Ennio; Del Soldato, Piero
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 441 - 446
